To install MySQL on a Mico S operating system, visit the official MySQL website's download page and select the OS-specific version, with options like compressed tar archives or DMG files. After selecting a DMG file to download, you must log in or register on the Oracle website since Oracle has acquired MySQL. Once logged in, download the DMG file, which is sizeable, and upon completion, open it to reveal a PKG installer. Run the installer, follow the prompts to continue and input the user password when requested to install the software. Configuring the MySQL server involves selecting a password encryption method, with the strongly recommended option available. Set a password for the root user, who has full administrative privileges. After installation, the installer can be deleted. In system preferences, you'll find a new MySQL icon for configuring the service, where you can start or stop MySQL and access further settings under the configuration tab.